Funded projects 2015-2018

Funded projects within Area A

• Single-molecule superresolution imaging of the X chromosome using oligopaints FISH technology (Dr. Asifa Akhtar)
• SGK sensors for in vitro/in vivo dissection of signaling controlling membrane dynamics  (Prof. Ralf Baumeister)
• Metabolic control of organization and assembly of the mitochondrial voltage dependent anion channel (VDAC) (PD Dr. Thomas Becker)
• Plasticity in synaptic transmission encoded by the dynamics and assembly of AMPA-type glutamate receptors (Prof. Bernd Fakler)
• Membrane signaling complexes: Analysis, Synthesis and Control (Prof. Carola Hunte)
• Nano-scale organization and dynamics of presynaptic Ca2+ channels (PD Dr. Akos Kulik)
• Cooperation and regulation of mitochondrial preprotein translocation networks (PD Dr. Nils Wiedemann)
• Timing of cell fate decisions by stem cell transcription factors (Dr. Daria Onichtchouk)
• Communication between co- and post-translational membrane protein targeting pathways (Prof. Sabine Rospert)
• De-orphanization and characterization of transcellular and intracellular signaling mechanisms of the orphan G-protein coupled receptor GP158 (Dr. Uwe Schulte)
• Dynamics of the Mitochondrial Proteome and Integration into Signalling Networks (Prof. Bettina Warscheid)

Funded projects within BIOSS B:

• Counting cilia: Unusual checkpoint control of the atypical Cyclin O (Ccno) Counting cilia: Unusual checkpoint control of the atypical Cyclin O (Ccno) regulating number and formation of multiple motile cilia  (Dr. Sebastian Arnolds)
• Characterisation of an ill-defined kinase in vivo. (Prof. Tilman Brummer)
• Charting the kinase-phosphatase-protease network driving pancreatic cancer (Prof. Tilman Brummer)
• Optogenetic control of dopaminergic neurogenesis (Prof. Wolfgang Driever)
• Investigating a novel role of the oncogene homolog DEK4 in Arabidopsis shoot meristem stem cell signaling (Prof. Thomas Laux)
• Regulation of Tip60S90 phosphorylation by CDK9: implications for a role in the regulation of transcription (Dr. Ulrich Maurer)
• Regulating developmental signaling by sorting at the plasma membrane (Dr. Giorgos Pyrowolakis)
• Elucidating functional networks of shed and secreted proteins in complex tumor microenvironments (Prof. Thomas Reinheckel, Prof. Christoph Peters, PD Dr. Oliver Schilling)
• Modelling epithelial cancers for targeting carcinogenesis and progression (Prof. Silke Laßmann, PD Dr. Oliver Schilling)
• Cilia as cellular stress sensors (Prof. Gerd Walz)
• Oncogenic signaling networks and interaction of tumors with the microenvironment  (Prof. Robert Zeiser)

Funded projects within BIOSS C

• Deep learning for automated image analysis in generic imaging modalities (Prof. Thomas Brox)
• Personalized Glyco-Engineered Complement Regulators for Complement-Associated Diseases (Prof. Ralf Reski)
• Design and analysis of an artificial transmembrane signalling system (Dr. Max Ulbrich)
• Characterisation of Phytochrome PfrPr Heterodimers and Implementation of a Far-Red Light Inducible Optogenetic Switch (Prof. Andreas Hiltbrunner)
• Dissecting signaling kinetics and regulatory feedback by optogenetics (Dr. Giorgos Pyrowolakis)
• A new multiplexing high throughput protein-protein-proximity assay for probing nano-scale protein organization and interaction in biological membrane (Dr. Jianying Yang)
• Novel optogenetic switches to control cell signaling (Prof. Wilfried Weber)
• Design-controlled activation of mouse T lymphocytes (Prof. Wolfgang Schamel)
• Effect of Stochastic Nanoroughness on Phenotype and Gene Expression Patterns in Astrocytes (Prof. Prasad Shastri)
• Role of CTSK-MP-9 Crosstalk in Epithelial Tumor Progression (Prof. Prasad Shastri)
• Lipid nano-clustering by external stimuli (Prof. Heiko Heerklotz, Prof. Winfried Römer)
• Mathematical modelling for BIOSS (Prof. Jens Timmer)
• Optogenetic control of signaling switches in mammalian cells  (Prof. Gerald Radziwill)
• Microfluidic In Situ Sequencing for revealing Signaling Transduction in Organoids (Dr. Matthias Meier)
• Metabolic Lipid Imaging with Raman Microscopy and Microfluidics (Dr. Matthias Meier)
• SELEX for synthetic biology and nanoscale applications (Prof. Rolf Backofen)