BIOSS-A
Membranes and protein–lipid interactions in signalling
BIOSS-B
Oncogenic signalling
BIOSS-C
Re-building & biotechnology
BIOSS
From Analysis
to Synthesis
Publications
- AWD regulates timed activation of BMP signaling in intestinal stem cells to maintain tissue homeostasis.
Tracy Cai X, Li H, Safyan A, Gawlik J, Pyrowolakis G, Jasper H (2019).
Nat Commun. 10(1):2988 - Sequence environment of BMP-dependent activating elements controls transcriptional responses to Dpp signaling in Drosophila.
Chayengia M, Veikkolainen V, Jevtic M, Pyrowolakis G (2019).
Development. 146(11). - Retrograde BMP signaling activates neuronal gene expression through widespread deployment of a conserved BMP-responsive cis-regulatory activation element.
Vuilleumier R, Lian T, Flibotte S, Khan ZN, Fuchs A, Pyrowolakis G, Allan DW (2019).
Nucleic Acids Res. 47(2):679-699. - Gene regulation during Drosophila eggshell patterning.
Pyrowolakis G, Veikkolainen V, Yakoby N, Shvartsman SY. (2017)
Proc Natl Acad Sci U S A. 114(23):5808-5813. - Sex-specific transcript diversity in the fly head is established during pupal stages and adulthood and is largely independent of the mating process and the germline.
Mohr C, Kleiner S, Blanchette M, Pyrowolakis G, Hartmann B. (2017)
Sex Dev. 11(2):94-108. - Pentagone internalises glypicans to fine-tune multiple signalling pathways.
Norman M, Vuilleumier R, Springhorn A, Gawlik J, Pyrowolakis G.
Elife. 2016 Jun 8;5. pii: e13301. - The protein kinase LKB1 negatively regulates bone morphogenetic protein receptor signaling.
Raja E, Tzavlaki K, Vuilleumier R, Edlund K, Kahata K, Zieba A, Morén A, Watanabe Y, Voytyuk I, Botling J, Söderberg O, Micke P, Pyrowolakis G, Heldin CH, Moustakas A. (2016)
Oncotarget. 7(2):1120-43. - DMP-dependent gene repression cascade in Drosophila eggshell patterning.
Charbonnier E, Fuchs A, Cheung LS, Chayengia M, Veikkolainen V, Seyfferth J, Shvartsman SY, Pyrowolakis G (2015).
Dev Biol. 400(2):258-65. - The Dpp/TGF?-dependent corepressor Schnurri protects epithelial cells from JNK-induced apoptosis in drosophila embryos.
Beira JV, Springhorn A, Gunther S, Hufnagel L, Pyrowolakis G, Vincent JP (2014).
Dev Cell. 31(2):240-7. - BMPs regulate msx gene expression in the dorsal neuroectoderm of Drosophila and vertebrates by distinct mechanisms.
Esteves FF, Springhorn A, Kague E, Taylor E, Pyrowolakis G, Fisher S, Bier E (2014).
PLoS Genet. 10(9):e1004625. - Regulation of broad by the Notch pathway affects timing of follicle cell development.
Jia D, Tamori Y, Pyrowolakis G, Deng WM (2014).
Dev Biol. 392(1):52-61. - Dpp/BMP signaling in flies: from molecules to biology.
Hamaratoglu F, Affolter M, Pyrowolakis G (2014).
Semin Cell Dev Biol. 32:128-36. - Dynamic model for the coordination of two enhancers of broad by EGFR signaling.
Cheung LS, Simakov DS, Fuchs A, Pyrowolakis G, Shvartsman SY (2013).
Proc Natl Acad Sci U S A. 110(44):17939-44 - Manipulating the sensitivity of signal-induced repression: quantification and consequences of altered brinker gradients.
Gafner L, Dalessi S, Escher E, Pyrowolakis G, Bergmann S, Basler K (2013).
PLoS One. 8(8):e71224 - The Drosophila BMPRII, Wishful thinking, is required for eggshell patterning.
Marnion R, Jevtic M, Springhorn A, Pyrowolakis G, Yakoby N (2013).
Dev Biol 375(1):45-53 - Transcriptional Interpretation of the EGFR Signaling Gradient.
Fuchs A, Cheung LS, Charbonnier E, Shvartsman SY,* Pyrowolakis G * (2012).
Proc Natl Acad Sci U S A, 109, 1572-77
(*shared senior authorship) - DPP signaling activity requires Pentagone to scale with tissue size in the growing Drosophila wing imaginal disc.
Hamaratoglu F, Morton de Lachapelle A, Pyrowolakis G, Bergmann S, Affolter M (2011).
PLOS Biol., 9, e1001182. - Expansion-Repression Mechanism for Scaling the Dpp Activation Gradient in Drosophila Wing Imaginal Discs.
Ben-Zvi D, Pyrowolakis G, Barkai N, Shilo BZ (2011).
Curr. Biol., 21, 1391-96. - Pentagone: Patrolling BMP morphogen signalling.
Vuilleumier R, Pyrowolakis G (2011).
Fly, 5, 210-14. - Control of Dpp morphogen distribution by a secreted feedback regulator.
Vuilleumier R, Springhorn A, Patterson L, Koidl S, Hammerschmidt M, Affolter M, Pyrowolakis G (2010).
Nat. Cell. Biol.,12, 611-617. - Dpp Signalling directs Cell Motility and Invasiveness during Epithelial Morphogenesis.
Ninov N, Manjon C, Menezes-Gabral S, Weiss A, Pyrowolakis G, Affolter M, Martin-Blanco E (2010).
Curr. Biol., 20, 513-520. - A conserved activation element in BMP signaling during Drosophila development.
Weiss A, Charbonnier E, Ellertsdóttir E, Wolf C, Schuh R, Pyrowolakis G*, Affolter M* (2010).
Nat. Struct. Mol. Biol., 19, 69-76.
(*shared senior authorship) - Signal-Induced Repression: The Exception or the Rule in Developmental Signaling?
Affolter M, Pyrowolakis G, Weiss A, Basler K (2008).
Dev. Cell 15, 11-22. - eIF4A goes beyond translation.
Affolter M, Pyrowolakis G (2006).
Nature Cell Biol., 15, 11-22. - BMP and Activin Signaling in Drosophila.
Pyrowolakis G, Hartmann B, Affolter M (2008).
In: The TGF-? Family (editors: Derynck R. and Miyazono K.), Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York. - A simple molecular complex mediates widespread BMP-induced repression during Drosophila development.
Pyrowolakis G, Hartmann B, Muller B, Basler K, Affolter M (2004).
Dev. Cell, 7, 229-240. - BRUCE, a Giant E2/E3 Ubiquitin Ligase and Inhibitor of Apoptosis Protein of the trans-Golgi Network, Is Required for Normal Placenta Development and Mouse Survival.
Lotz C*, Pyrowolakis G* Jentsch S (2004).
Mol. Biol. Cell, 24, 9339-50.
(*equal contribution) - Dual Role of BRUCE as an Antiapoptotic IAP and a Chimeric E2/E3 Ubiquitin Ligase.
Bartke T, Pohl C, Pyrowolakis G, Jentsch S (2004).
Mol. Cell, 14, 801-11. - The ubiquitin-like protein HUB1 forms SDS-resistant complexes with cellular proteins in the absence of ATP.
Luders J, Pyrowolakis G, Jentsch S (2003).
EMBO Rep., 4, 1169-74. - Conversion of an extracellular Dpp/BMP morphogen gradient into an inverse transcriptional gradient.
Müller B*, Hartmann B*, Pyrowolakis G*, Affolter M, Basler K (2003).
Cell, 113, 221-33.
(*equal contribution) - RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO.
Hoege C, Pfander B, Moldovan GL, Pyrowolakis G, Jentsch S (2002).
Nature, 419, 135-41. - SUMO, Ubiquitin's mysterious cousin.
Müller S, Hoege C, Pyrowolakis G, Jentsch S (2001).
Nat. Rev. Mol. Cell Biol., 2, 202-10. - Ubiquitin and its kin: how close are the family ties?
Jentsch S, Pyrowolakis G (2000).
Trends Cell Biol., 10, 335-42. - A giant ubiquitin-conjugating enzyme related to IAP apoptosis inhibitors
Hauser HP, Bardroff M, Pyrowolakis G, Jentsch S (1998).
J. Cell Biol., 141, 1415-22. - The subunit b of the F0F1-type ATPase of the bacterium Mycoplasma pneumaniae is a lipoprotein.
Pyrowolakis G, Hoffmann D, Herrmann R (1998).
J. Biol. Chem., 273, 24792-6.