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Publications
- Structural mechanism for inhibition of PP2A-B56α and oncogenicity by CIP2A.
Pavic K, Gupta N, Omella JD, Derua R, Aakula A, Huhtaniemi R, Määttä JA, Höfflin N, Okkeri J, Wang Z, Kauko O, Varjus R, Honkanen H, Abankwa D, Köhn M, Hytönen VP, Xu W, Nilsson J, Page R, Janssens V, Leitner A, Westermarck J.
Nat Commun. 2023 Feb 28;14(1):1143. - Exploring Uncharted Territory: Toward Metabolite Network Maps.
Dürr EM, Köhn M.
ACS Cent Sci. 2022 Dec 28;8(12):1576-1578. y - Membrane targeting with palmitoylated lysine added to PP1-disrupting peptide induces PP1-independent signaling.
Chojnacki JE, Scheinost L, Wang Y, Köhn M.
J Pept Sci. 2022 Dec 16:e3469. - Emerging insights into serine/threonine-specific phosphoprotein phosphatase function and selectivity.
Kokot T, Köhn M.
J Cell Sci. 2022 Oct 1;135(19):jcs259618. - PLDMS: Phosphopeptide Library Dephosphorylation Followed by Mass Spectrometry Analysis to Determine the Specificity of Phosphatases for Dephosphorylation Site Sequences.
Kokot T, Hoermann B, Helm D, Chojnacki JE, Savitski MM, Köhn M.
Methods Mol Biol. 2022;2499:43-64. - Short peptide pharmacophores developed from protein phosphatase-1 disrupting peptides (PDPs).
Fontanillo M, Trebacz M, Reinkemeier CD, Avilés Huerta D, Uhrig U, Sehr P, Köhn M.
Bioorg Med Chem. 2022 Jul 1;65:116785 - finDr: A web server for in silico D-peptide ligand identification.
Engel H, Guischard F, Krause F, Nandy J, Kaas P, Höfflin N, Köhn M, Kilb N, Voigt K, Wolf S, Aslan T, Baezner F, Hahne S, Ruckes C, Weygant J, Zinina A, Akmeriç EB, Antwi EB, Dombrovskij D, Franke P, Lesch KL, Vesper N, Weis D, Gensch N, Di Ventura B, Öztürk MA.
Synth Syst Biotechnol. 2021 Nov 23;6(4):402-413. - Biosensor-Enabled Multiplexed On-Site Therapeutic Drug Monitoring of Antibiotics.
Ates HC, Mohsenin H, Wenzel C, Glatz RT, Wagner HJ, Bruch R, Höfflin N, Spassov S, Streicher L, Lozano-Zahonero S, Flamm B, Trittler R, Hug MJ, Köhn M, Schmidt J, Schumann S, Urban GA, Weber W, Dincer C.
Adv Mater. 2021 Sep 21:e2104555. - Quantitative proteomics identifies PTP1B as modulator of B cell antigen receptor signaling.
Schwarz JJ, Grundmann L, Kokot T, Kläsener K, Fotteler S, Medgyesi D, Köhn M, Reth M, Warscheid B
Life Science Alliance 2021, 4, Published 15 September 2021. DOI: 10.26508/lsa.202101084 - Maintaining proteostasis under mechanical stress.
Höhfeld J, Benzing T, Bloch W, Fürst DO, Gehlert S, Hesse M, Hoffmann B, Hoppe T, Huesgen PF, Köhn M, Kolanus W, Merkel R, Niessen CM, Pokrzywa W, Rinschen MM, Wachten D, Warscheid B. EMBO Rep. 2021 Aug 4;22(8):e52507. - DTL-DephosSite: Deep Transfer Learning Based Approach to Predict Dephosphorylation Sites.
Chaudhari M, Thapa N, Ismail H, Chopade S, Caragea D, Köhn M, Newman RH, Kc DB.
Front Cell Dev Biol. 2021 Jun 24;9:662983. - The phosphatase PRL-3 affects intestinal homeostasis by altering the crypt cell composition.
Rubio T, Weyershaeuser J, Montero MG, Hoffmann A, Lujan P, Jechlinger M, Sotillo R, Köhn M.
J Mol Med (Berl). 2021 Jun 15. Online ahead of print. - Evolutionary crossroads of cell signaling: PP1 and PP2A substrate sites in intrinsically disordered regions.
Hoermann B, Köhn M.
Biochem Soc Trans. 2021 Jun 30;49(3):1065-1074. - Cross-TCR Antagonism Revealed by Optogenetically Tuning the Half-Life of the TCR Ligand Binding.
Yousefi OS, Ruggieri M, Idstein V, von Prillwitz KU, Herr LA, Chalupsky J, Köhn M, Weber W, Timmer J, Schamel WWA.
Int J Mol Sci. 2021 May 6;22(9):4920. - The Leishmania donovani LDBPK_220120.1 Gene Encodes for an Atypical Dual Specificity Lipid-Like Phosphatase Expressed in Promastigotes and Amastigotes; Substrate Specificity, Intracellular Localizations, and Putative Role(s).
Papadaki A, Tziouvara O, Kotopouli A, Koumarianou P, Doukas A, Rios P, Tardieux I, Köhn M, Boleti H.
Front Cell Infect Microbiol. 2021 Mar 25;11:591868 - Structural basis of Naa20 activity towards a canonical NatB substrate.
Layer D, Kopp J, Fontanillo M, Köhn M, Lapouge K, Sinning I.
Commun Biol. 2021 Jan 4;4(1):2. - Protein tyrosine phosphatases in multiple myeloma.
Abdollahi P, Köhn M, Børset M.
Cancer Lett. 2021 Mar 31;501:105-113. - Towards Dissecting the Mechanism of Protein Phosphatase-1 Inhibition by Its C-Terminal Phosphorylation.
Salvi F, Hoermann B, Del Pino García J, Fontanillo M, Derua R, Beullens M, Bollen M, Barabas O, Köhn M.
Chembiochem. 2021 Mar 2;22(5):834-838. - Noncanonical binding of Lck to CD3ε promotes TCR signaling and CAR function.
Hartl FA, Beck-Garcìa E, Woessner NM, Flachsmann LJ, Cárdenas RMV, Brandl SM, Taromi S, Fiala GJ, Morath A, Mishra P, Yousefi OS, Zimmermann J, Hoefflin N, Köhn M, Wöhrl BM, Zeiser R, Schweimer K, Günther S, Schamel WW, Minguet S.
Nat Immunol. 2020 Aug;21(8):902-913. - Dissecting the sequence determinants for dephosphorylation by the catalytic subunits of phosphatases PP1 and PP2A.
Hoermann B, Kokot T, Helm D, Heinzlmeir S, Chojnacki JE, Schubert T, Ludwig C, Berteotti A, Kurzawa N, Kuster B, Savitski MM, Köhn M.
Nat Commun. 2020 Jul 17;11(1):3583. - The receptor PTPRU is a redox sensitive pseudophosphatase.
Hay IM, Fearnley GW, Rios P, Köhn M, Sharpe HJ, Deane JE.
Nat Commun. 2020 Jun 26;11(1):3219. - Turn and Face the Strange: A New View on Phosphatases.
Köhn M.
ACS Cent Sci. 2020 Apr 22;6(4):467-477. - Development of a photoactivatable protein phosphatase-1-disrupting peptide.
Trebacz M, Wang Y, Makotta L, Henschke L, Köhn M.
J Org Chem. 2020 Feb 7;85(3):1712-1717 - The human DEPhOsphorylation Database DEPOD: 2019 update.
Damle NP, Köhn M.
Database (Oxford). 2019 Jan 1;2019. - Structural and mechanistic insights into the interaction of the circadian transcription factor BMAL1 with the KIX domain of the CREB-binding protein.
Garg A, Orru R, Ye W, Distler U, Chojnacki JE, Köhn M, Tenzer S, Sönnichsen C, Wolf E.
J Biol Chem. 2019 Nov 8;294(45):16604-16619. - The cholesterol transfer protein GRAMD1A regulates autophagosome biogenesis.
Laraia L, Friese A, Corkery DP, Konstantinidis G, Erwin N, Hofer W, Karatas H, Klewer L, Brockmeyer A, Metz M, Schölermann B, Dwivedi M, Li L, Rios-Munoz P, Köhn M, Winter R, Vetter IR, Ziegler S, Janning P, Wu YW, Waldmann H.
Nat Chem Biol. 2019 Jul;15(7):710-720. - Protein kinase/phosphatase balance mediates the effects of increased late sodium current on ventricular calcium cycling.
Eiringhaus J, Herting J, Schatter F, Nikolaev VO, Sprenger J, Wang Y, Köhn M, Zabel M, El-Armouche A, Hasenfuss G, Sossalla S, Fischer TH.
Basic Res Cardiol. 2019 Feb 20;114(2):13. - Interrogating PP1 activity in the MAPK pathway with optimized PP1-disrupting peptides.
Wang Y, Hoermann B, Pavic K, Trebacz M, Rios P, Köhn M.
Chembiochem. 2019;20(1):66-71. - Effects of stably incorporated iron on protein phosphatase-1 structure and activity.
Salvi F, Trebacz M, Kokot T, Hoermann B, Rios P, Barabas O, Kӧhn M.
FEBS Lett. 2018 Dec;592(24):4028-4038. - Activation of protein phosphatase 1 by a selective phosphatase disrupting peptide reduces sarcoplasmic reticulum Ca2+ leak in human heart failure.
Fischer TH, Eiringhaus J, Dybkova N, Saadatmand A, Pabel S, Weber S, Wang Y, Köhn M, Tirilomis T, Ljubojevic S, Renner A, Gummert J, Maier LS, Hasenfuß G, El-Armouche A, Sossalla S.
Eur J Heart Fail. 2018 Dec;20(12):1673-1685. - Mutational analysis of a conserved glutamate reveals unique mechanistic and structural features of the phosphatase PRL-3
Höger B, Rios P, Berteotti A, Hoermann B, Duan G, Köhn M.
ACS Omega 2017;2(12):9171–9180 - Keep it on the edge: The post-mitotic midbody as a polarity signal unit
Lujan P, Rubio T, Varsano G, Köhn M
Commun. Integr. Biol. 2017, 10, e1338990 - Microcystins: Synthesis and structure-activity relationship studies toward PP1 and PP2A.
Fontanillo M, Köhn M.
Bioorg Med Chem. 2018 Mar 15;26(6):1118-1126. - Miklós Bodanszky Award Lecture: Advances in the selective targeting of protein phosphatase-1 and phosphatase-2A with peptides.
Köhn M.
J Pept Sci. 2017 Oct;23(10):749-756. - Mouse Rif1 is a regulatory subunit of protein phosphatase 1 (PP1).
Sukackaite R, Cornacchia D, Jensen MR, Mas PJ, Blackledge M, Enervald E, Duan G, Auchynnikava T, Köhn M, Hart DJ, Buonomo SBC.
Sci Rep. 2017 May 18;7(1):2119. - Regulatory mechanisms of phosphatase of regenerating liver (PRL)-3.
Rubio T, Köhn M.
Biochem Soc Trans. 2016 Oct 15;44(5):1305-1312. Review. - PRL-3 disrupts epithelial architecture by altering the post-mitotic midbody position.
Luján P, Varsano G, Rubio T, Hennrich ML, Sachsenheimer T, Gálvez-Santisteban M, Martín-Belmonte F, Gavin AC, Brügger B, Köhn M.
J Cell Sci. 2016 Nov 1;129(21):4130-4142. - Synthesis of Highly Selective Submicromolar Microcystin-Based Inhibitors of Protein Phosphatase (PP)2A over PP1.
Fontanillo M, Zemskov I, Häfner M, Uhrig U, Salvi F, Simon B, Wittmann V, Köhn M.
Angew Chem Int Ed Engl. 2016 Nov 2;55(45):13985-13989. - Approaches to Study Phosphatases.
Fahs S, Lujan P, Köhn M.
ACS Chem Biol. 2016 Nov 18;11(11):2944-2961. - Phosphatases: Their Roles in Cancer and Their Chemical Modulators.
Fontanillo M, Köhn M.
Adv Exp Med Biol. 2016;917:209-40. - Prediction and verification of novel peptide targets of protein tyrosine phosphatase 1B
Li X, Köhn M.
Bioorg Med Chem. 2016 Aug 1;24(15):3255-8. - Rapid erasure of hippocampal memory following inhibition of dentate gyrus granule cells.
Madroñal N, Delgado-García JM, Fernández-Guizán A, Chatterjee J, Köhn M, Mattucci C, Jain A, Tsetsenis T, Illarionova A, Grinevich V, Gross CT, Gruart A.
Nat Commun. 2016 Mar 18;7:10923. - Procyanidins negatively affect the activity of the phosphatases of regenerating liver.
Stadlbauer S, Rios P, Ohmori K, Suzuki K, Köhn M.
PLoS One. 2015 Jul 30;10(7):e0134336. - Chemistry and biology of protein and inositol phosphorylation.
Köhn M.
Bioorg Med Chem. 2015 Jun 15;23(12):2747-8. - Azide-alkyne cycloaddition-mediated cyclization of phosphonopeptides and their evaluation as PTP1B binders and enrichment tools.
Meyer C, Hoeger B, Chatterjee J, Köhn M.
Bioorg Med Chem. 2015 Jun 15;23(12):2848-53. - Synthesis of hydrolysis-resistant pyridoxal 5'-phosphate analogs and their biochemical and X-ray crystallographic characterization with the pyridoxal phosphatase chronophin.
Knobloch G, Jabari N, Stadlbauer S, Schindelin H, Köhn M, Gohla A.
Bioorg Med Chem. 2015 Jun 15;23(12):2819-27. - VHR/DUSP3 phosphatase: structure, function and regulation.
Pavic K, Duan G, Köhn M.
FEBS J. 2015 May;282(10):1871-90. - The human DEPhOsphorylation database DEPOD: a 2015 update.
Duan G, Li X, Köhn M.
Nucleic Acids Res. 2015 Jan;43(Database issue):D531-5. - Biochemical evaluation of virtual screening methods reveals a cell-active inhibitor of the cancer-promoting phosphatases of regenerating liver.
Hoeger B, Diether M, Ballester PJ, Köhn M.
Eur J Med Chem. 2014 Dec 17;88:89-100. - Building up a chemical proteomics network in Europe and beyond.
Köhn M, Meijler MM, Kaiser M.
ACS Chem Biol. 2014 Aug 15;9(8):1647-8. - Unnatural amino acid mutagenesis reveals dimerization as a negative regulatory mechanism of VHR's phosphatase activity.
Pavic K, Rios P, Dzeyk K, Koehler C, Lemke EA, Köhn M.
ACS Chem Biol. 2014 Jul 18;9(7):1451-9. - Design and Application of Chemical Probes for Protein Serine/Threonine Phosphatase Activation
Wang Y, Köhn M.
in H. Waldmann, P. Janning (Eds.) “Concepts and Case Studies in Chemical Biology”, Wiley-VCH, Weinheim, 2014 (book chapter). - Strategies for Designing Specific Protein Tyrosine Phosphatase Inhibitors and their Intracellular Activation
Hoeger B, Köhn M.
in H. Waldmann, P. Janning (Eds.) “Concepts and Case Studies in Chemical Biology”, Wiley-VCH, Weinheim, 2014 (book chapter). - Was ist was? Biochemie, Chemische Biologie et al. (What is what? Biochemistry, chemical biology et al.)
Köhn M.
Nachrichten aus der Chemie 2014, 2, 142-144. - Development of accessible peptidic tool compounds to study the phosphatase PTP1B in intact cells.
Meyer C, Hoeger B, Temmerman K, Tatarek-Nossol M, Pogenberg V, Bernhagen J, Wilmanns M, Kapurniotu A, Köhn M.
ACS Chem Biol. 2014 Mar 21;9(3):769-76. - Dual-specificity phosphatases as molecular targets for inhibition in human disease.
Ríos P, Nunes-Xavier CE, Tabernero L, Köhn M, Pulido R.
Antioxid Redox Signal. 2014 May 10;20(14):2251-73. - Chemical activators of protein phosphatase-1 induce calcium release inside intact cells.
Reither G, Chatterjee J, Beullens M, Bollen M, Schultz C, Köhn M.
Chem Biol. 2013 Sep 19;20(9):1179-86. - Elucidating human phosphatase-substrate networks.
Li X, Wilmanns M, Thornton J, Köhn M.
Sci Signal. 2013 May 14;6(275):rs10. Highlighted by “SciBX: Science-Business eXchange” and “ProteoMonitor”. - Targeting the untargetable: recent advances in the selective chemical modulation of protein phosphatase-1 activity.
Chatterjee J, Köhn M.
Curr Opin Chem Biol. 2013 Jun;17(3):361-8. - Challenges and opportunities in the development of protein phosphatase-directed therapeutics.
De Munter S, Köhn M, Bollen M.
ACS Chem Biol. 2013 Jan 18;8(1):36-45. - Development of a peptide that selectively activates protein phosphatase-1 in living cells.
Chatterjee J, Beullens M, Sukackaite R, Qian J, Lesage B, Hart DJ, Bollen M, Köhn M.
Angew Chem Int Ed Engl. 2012 Oct 1;51(40):10054-9. - A molecular tête-à-tête arranged by a designed adaptor protein.
Meyer C, Köhn M.
Angew Chem Int Ed Engl. 2012 Aug 13;51(33):8160-2. - Chemical biology techniques unlock the secrets of casein kinase 2 regulation by phosphorylation and glycosylation.
Pavic K, Köhn M.
Chembiochem. 2012 Jun 18;13(9):1253-5. - Development of a solid phase synthesis strategy for soluble phosphoinositide analogues
Bru M, Kotkar SP, Kar N, Köhn M.
Chem Sci. 2012;3:1893-1902. - Omics and chemical biology--a powerful synergism.
Köhn M.
Curr Opin Chem Biol. 2012 Apr;16(1-2):204-5. - Molecular mechanisms of the PRL phosphatases.
Rios P, Li X, Köhn M.
FEBS J. 2013 Jan;280(2):505-24. - The metastasis-promoting phosphatase PRL-3 shows activity toward phosphoinositides.
McParland V, Varsano G, Li X, Thornton J, Baby J, Aravind A, Meyer C, Pavic K, Rios P, Köhn M.
Biochemistry. 2011 Sep 6;50(35):7579-90. - Efficient scaled-up synthesis of N-α-Fmoc 4-phosphono(difluoromethyl)-L-phenylalanine and its incorporation into peptides
Meyer C, Köhn M.
Synthesis 2011;20:3255-3260. - Preparation of biomolecule microstructures and microarrays by thiol-ene photoimmobilization.
Weinrich D, Köhn M, Jonkheijm P, Westerlind U, Dehmelt L, Engelkamp H, Christianen PC, Kuhlmann J, Maan JC, Nüsse D, Schröder H, Wacker R, Voges E, Breinbauer R, Kunz H, Niemeyer CM, Waldmann H.
Chembiochem. 2010 Jan 25;11(2):235-47. - Structure-activity analysis of semisynthetic nucleosomes: mechanistic insights into the stimulation of Dot1L by ubiquitylated histone H2B.
McGinty RK, Köhn M, Chatterjee C, Chiang KP, Pratt MR, Muir TW.
ACS Chem Biol. 2009 Nov 20;4(11):958-68. - Immobilization strategies for small molecule, peptide and protein microarrays.
Köhn M.
J Pept Sci. 2009 Jun;15(6):393-7. - Chemical biologists gather in Heidelberg.
Köhn M, Schultz C.
Nat Chem Biol. 2009 Feb;5(2):66-9. - Photochemical surface patterning by the thiol-ene reaction.
Jonkheijm P, Weinrich D, Köhn M, Engelkamp H, Christianen PC, Kuhlmann J, Maan JC, Nüsse D, Schroeder H, Wacker R, Breinbauer R, Niemeyer CM, Waldmann H.
Angew Chem Int Ed Engl. 2008;47(23):4421-4. - Simultaneous protein tagging in two colors.
Schultz C, Köhn M.
Chem Biol. 2008 Feb;15(2):91-2. - A microarray strategy for mapping the substrate specificity of protein tyrosine phosphatase.
Köhn M, Gutierrez-Rodriguez M, Jonkheijm P, Wetzel S, Wacker R, Schroeder H, Prinz H, Niemeyer CM, Breinbauer R, Szedlacsek SE, Waldmann H.
Angew Chem Int Ed Engl. 2007;46(40):7700-3. - A generic building block for C- and N-terminal protein-labeling and protein-immobilization.
Watzke A, Gutierrez-Rodriguez M, Köhn M, Wacker R, Schroeder H, Breinbauer R, Kuhlmann J, Alexandrov K, Niemeyer CM, Goody RS, Waldmann H.
Bioorg Med Chem. 2006 Sep 15;14(18):6288-306. - Site-selective protein immobilization by Staudinger ligation.
Watzke A, Köhn M, Gutierrez-Rodriguez M, Wacker R, Schröder H, Breinbauer R, Kuhlmann J, Alexandrov K, Niemeyer CM, Goody RS, Waldmann H.
Angew Chem Int Ed Engl. 2006 Feb 20;45(9):1408-12. - Diels-Alder ligation and surface immobilization of proteins.
de Araújo AD, Palomo JM, Cramer J, Köhn M, Schröder H, Wacker R, Niemeyer C, Alexandrov K, Waldmann H.
Angew Chem Int Ed Engl. 2005 Dec 23;45(2):296-301. - The Staudinger ligation-a gift to chemical biology.
Köhn M, Breinbauer R.
Angew Chem Int Ed Engl. 2004 Jun 14;43(24):3106-16. - Functional evaluation of carbohydrate-centred glycoclusters by enzyme-linked lectin assay: ligands for concanavalin A.
Köhn M, Benito JM, Ortiz Mellet C, Lindhorst TK, García Fernández JM.
Chembiochem. 2004 Jun 7;5(6):771-7. - Small molecule arrays
Breinbauer R, Köhn M, Peters C.
in C. Schmuck, H. Wennemers (Eds.) “Highlights in Bioorganic Chemistry; Wiley-VCH, Weinheim, 2004. (book chapter) - Staudinger ligation: a new immobilization strategy for the preparation of small-molecule arrays.
Köhn M, Wacker R, Peters C, Schröder H, Soulère L, Breinbauer R, Niemeyer CM, Waldmann H.
Angew Chem Int Ed Engl. 2003;42(47):5830-4. - Azide-alkyne coupling: a powerful reaction for bioconjugate chemistry.
Breinbauer R, Köhn M.
Chembiochem. 2003 Nov 7;4(11):1147-9.