Program

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THURSDAY, 28th February 2019

09:00 Registration and Welcome with coffee

09:45 Presentation of the seminar (Reinhard Voll, Freiburg; Anne-Sophie Korganow, Strasbourg)

10:00 Primary (PID) and secondary immunodeficiency (SID): clinical problem and diagnostic approach (Hans Hartmut Peter,
Freiburg)

10:30 COFFEE BREAK

10:45 B lymphocyte development (Pauline Soulas-Sprauel, Strasbourg)

11:15 Agammaglobulinemia (Marta Rizzi, Freiburg)

11:45 Hypogammaglobulinemia (Klaus Warnatz, Freiburg)

12:15 LUNCH

13:30 Treatment of hypogammaglobulinemia (Mike Recher, Basel)

14:00 Secondary immunodeficiencies (Jens Thiel, Freiburg)

14:30 SRP54, a new gene for severe congenital neutropenia (Raphael Carapito, Strasbourg

15:00 COFFEE BREAK

15:15 TLRs defects (Frederic Gros, Strasbourg)

15:45 WORKSHOP 1 – B lymphocytes and primary immunodeficiency (Thierry Martin, Strasbourg)

15:45 B-Cells: Maturation and adaptive immune response (Peter Felixberger, Freiburg)

16:00 Modeling of early B cell development in Primary Antibody Deficiencies (Arianna Troilo, Freiburg)

16:15 Defects in plasma cell differentiation are associated with primary immunodeficiency in human subjects (Quentin
Reuschlé, Strasbourg)

16:30 Lymphoma and Primary Immunodeficiencies : a systematic review (Mathilde Herber, Strasbourg)

16:45 Loss of ARHGEF1 causes a human primary antibody deficiency (Yannick Dieudonné, Strasbourg)

16:45 COFFEE BREAK

17:15 WORKSHOP 2 - Genetic defects and clinical aspects (Marta Rizzi, Freiburg)

17:15 Presentation of a new primary immune deficiency (Floriane Kaelbel, Strasbourg)

17:30 Metabolic changes in CD20ko cells (Kathrin Klaesener, Freiburg)

17:45 Interaction of leukocytes in autoimmune myocardial inflammation (Lennard Halle, Freiburg)

18:00 Pulmonary Cryptococcosis and NK cells deficiency (Martin Martinot, Colmar)

18:15 Lymproliferative syndrome associated with EBV susceptibility- about 2 cases reports (Sarah Jannier, Strasbourg)

18:30 PID and autoinflammatory syndromes (Philippe Mertz, Strasbourg)

19:00 DINNER

FRIDAY, 1st March, 2019

09:00 T cell activation and signalling (Susana Minguet, Freiburg)

09:30 P-CID SCID T cell immunodeficiency (Casten Speckmann, Freiburg)

10:00 Cytotoxicity deficiencies (HLH, MAS) (Stephan Ehl, Freiburg)

10:30 COFFEE BREAK

11:00 WORKSHOP 3 – Mechanisms in primary immunodeficiency (Pauline Soulas-Sprauel, Strasbourg)

11:00 Germline HAVCR2 mutations altering TIM-3 characterize subcutaneous panniculitis-like T cell lymphomas with
hemophagocytic lymphohistiocytic syndrome (Markus Schramm, Freiburg)

11:15 NN (Kathryn Payne, Freiburg)

11:30 Modulation of B cell activation via DAXX-dependent Fas signaling (Julika Neumann, Freiburg)

11:45 Cytotoxic function of CD8 T lymphocytes with actin cytoskeletal abnormalities (Lara Althaus, Freiburg)

12:15 Severe combined immunodeficiency in a mouse model of STING gain of function (Stéphane Giorgiutti, Strasbourg)

12:30 LUNCH

13:45 Glucocorticoids, friends or foes? (Anne-Sophie Korganow, Strasbourg)

14:00 The fight against candida: Why do we need Th17 cells? (Bodo Grimbacher, Freiburg)

14:30 ImmunoTORopathies (Sophie Jung, Strasbourg)

15:00 COFFEE BREAK

15:15 Cytokine pathway defects (Anne-Sophie Korganow, Strasbourg)

15:45 Workshop 4 – Immunomodulation and cytokine signaling (Sophie Jung, Strasbourg)

15:45 IL-10 mediates plasmacytosis-associated immunodeficiency by inhibiting complement-mediated neutrophil
migration (Anna-Lena Schäfer, Freiburg)

16:00 Abatacept modulates antigen presenting function and memory formation in human B cells (Raquel Lorenzetti,
Freiburg)

16:15 Jak inhibitors and B lymphocytes development (Janika Hüppe, Freiburg)

16:30 Immunodeficiency induced by Janus kinase inhibitors (Eden Sebbag, Strasbourg)

16:45 Antibiotic induced IgA deficiency (Olivier Vollmer, Strasbourg)

16:30 End of BBI – Farewell (Anne-Sophie Korganow, Strasbourg; Reinhard Voll, Freiburg)