Prof. Dr. Jens Timmer

Dynamic processes are ubiquitous in the life sciences. They can be found from the regulation in cells up to oscillations in tremor. Malfunction of these dynamical processes can be a cause or a sign of diseases. In interdisciplinary projects, the group "Data Analysis and Modeling of Dynamic Processes in the Life Sciences"  of Prof. Timmer develops and applies mathematical methods to analyse and model these processes based on measured data.
The final aim is to help to turn the life sciences from a qualitative descriptive into a quantitative predictive science.

10 selected publications:

• Pluripotency factors determine gene expression repertoire at zygotic genome activation.
  Gao M, Veil M, Rosenblatt M, Riesle AJ, Gebhard A, Hass H, Buryanova L, Yampolsky LY, Grüning B, Ulianov SV, Timmer J, Onichtchouk D.
  Nat Commun. 2022 Feb 10;13(1):788
• PULSE: Optogenetic control of gene expression in plants insensitive to ambient light.
  Ochoa-Fernandez R, Abel NB, Wieland FG, Schlegel J, Koch LA, Miller B, Engesser R, Giuriani G, Brandl SM, Timmer J, Weber W, Ott T, Simon R, Zurbriggen MD (2020).
  Nature Methods 17, 717-725
• Synthetic biology-inspired design of signal-amplifying materials systems.
  Wagner HJ, Engesser R, Ermes K, Geraths C, Timmer J, Weber W (2019).
  Materials Today 22, 25-34
• Phytochrome-Based Extracellular Matrix with Reversibly Tunable Mechanical Properties.
  Hörner M, Raute K, Hummel B, Madl J, Creusen G, Thomas OS, Christen EH, Hotz N, Gübeli RJ, Engesser R, Rebmann B, Lauer J, Rolauffs B, Timmer J, Schamel WWA, Pruszak J, Römer W, Zurbriggen MD, Friedrich C, Walther A, Minguet S, Sawarkar R, Weber W (2019).
  Adv Mater. 31(12):e1806727.
• Driving the model to its limit: Profile likelihood based model reduction.
  Maiwald T, Hass H, Steiert B, Vanlier J, Engesser R, Raue A, Kipkeew F, Bock HH, Kaschek D, Kreutz C, Timmer J (2016).
  PLoS One 11, e0162366.
• Multi-chromatic control of mammalian gene expression and signaling.
  Müller K, Engesser R, Schulz S, Steinberg T, Tomakidi P, Weber CC, Ulm R, Timmer J, Zurbriggen MD, Weber W (2013).
  Nucleic Acids Res. 41, e124.
• A red/far-red light-responsive bi-stable toggle switch to control gene expression in mammalian cells.
  Müller K, Engesser R, Metzger S, Schulz S, Kämpf MM, Busacker M, Steinberg T, Tomakidi P, Ehrbar M, Nagy F, Timmer J, Zubriggen MD, Weber W (2013).
  Nucleic Acids Res. 41, e77.
• Photoconversion and nuclear trafficking cycles determine phytochrome A's response profile to far-red light.
  Rausenberger J, Tscheuschler A, Nordmeier W, Wüst F, Timmer J, Schäfer E, Fleck C, Hiltbrunner A (2011).
  Cell 146, 813-25.
• Zebrafish Pou5f1-dependent transcriptional networks in temporal control of early development.
  Onichtchouk D, Geier F, Polok B, Messerschmidt DM, Mössner R, Wendik B, Song S, Taylor V, Timmer J, Driever W (2010).
  Mol Syst Biol. 6, 354.
• Covering a broad dynamic range: information processing at the erythropoietin receptor.
  Becker V, Schilling M, Bachmann J, Baumann U, Raue A, Maiwald T, Timmer J, Klingmüller U (2010).
  Science 328, 1404-8.