Prof. Dr. Maja Köhn (BIOSS Vice Speaker)

DEPOD – the dephosphorylation database

10 selected publications

• Emerging insights into serine/threonine-specific phosphoprotein phosphatase function and selectivity.
  Kokot T, Köhn M (2022).
  J Cell Sci. 135(19):jcs259618.
• The phosphatase PRL-3 affects intestinal homeostasis by altering the crypt cell composition.
  Rubio T, Weyershaeuser J, Montero MG, Hoffmann A, Lujan P, Jechlinger M*, Sotillo R*, Köhn M* (2021)
  J Mol Med. (Berlin) 99(10):1413-1426
• Dissecting the sequence determinants for dephosphorylation by the catalytic subunits of phosphatases PP1 and PP2A.
  Hoermann B, Kokot T, Helm D, Heinzlmeir S, Chojnacki JE, Schubert T, Ludwig C, Berteotti A, Kurzawa N, Kuster B, Savitski MM, Köhn M (2020).
  Nat Commun. 11(1):3583
• Turn and face the strange: A new view on phosphatases.
  Köhn M (2020)
  ACS Cent Sci. 6(4):467-477
• Molecular mechanism of SHP2 activation by PD-1 stimulation.
  Marasco M, Berteotti A, Weyershaeuser J, Thorausch N, Sikorska J, Krausze J, Brandt HJ, Kirkpatrick J, Rios P, Schamel WW, Köhn M*, Carlomagno T* (2020)
  Sci Adv. 2020/6: eaay4458.
• The human DEPhOsphorylation database DEPOD: a 2019 update.
  Damle NP, Köhn M (2019).
  Database (Oxford). 2019, baz133. doi: 10.1093/database/baz133.
• Activation of protein phosphatase 1 by a selective phosphatase disrupting peptide reduces sarcoplasmic reticulum Ca2+ leak in human heart failure.
  Fischer TH, Eiringhaus J, Dybkova N, Saadatmand A, Pabel S, Weber S, Wang Y, Köhn M, Tirilomis T, Ljubojevic S, Renner A, Gummert J, Maier LS, Hasenfuß G, El-Armouche A, Sossalla S (2018).
  Eur J Heart Fail. 20(12):1673-1685.
• PRL-3 disrupts epithelial architecture by altering the post-mitotic midbody position.
  Luján P, Varsano G, Rubio T, Hennrich ML, Sachsenheimer T, Gálvez-Santisteban M, Martín-Belmonte F, Gavin AC, Brügger B, Köhn M (2016).
  J Cell Sci. 129, 4130-4142.
• Elucidating human phosphatase-substrate networks.
  Li X, Wilmanns M, Thornton J, Köhn M (2013).
  Sci Signal. 6, 275, rs10.
• Development of a peptide that selectively activates protein phosphatase-1 in living cells.
  Chatterjee J, Beullens M, Sukackaite R, Qian J, Lesage B, Hart DJ, Bollen M*, Köhn M* (2012).
  Angew Chem Int Ed. 51, 10054-9.