Prof. Dr. Ralf Baumeister

10 selected publications:

• Mitochondrial perturbations couple mTORC2 to autophagy in C. elegans.
  Aspernig H, Heimbucher T, Qi W, Gangurde D, Curic S, Yan Y, Donner von Gromoff E, Baumeister R(*), Thien A. (2019) *corresponding author.
  Cell Rep. 5; 29(6): 1399-1409.
• Retromer and TBC1D5 maintain late endosomal RAB7 domains to enable amino acid-induced mTORC1 signalling.
  Kvainickas A, Nägele H, Qi W, Dokladal L, Jimenez-Orgaz A, Hu Z, Stehl L, Gangurde, D, Zhao Q, Hu Z, Dengjel J, de Virgilio C, Baumeister R, Steinberg F (2019).
  J Cell Biol 218(9): 3019-3038.
• C. elegans DAF-16/FOXO interacts with TGF-ß/BMP signaling to induce germline tumor formation via mTORC1 activation.
  Qi W, Yan Y, Pfeifer D, Donner V Gromoff E, Wang Y, Maier W, Baumeister R (2017).
  PLoS Genet. 13(5):e1006801
• TSC1 activates TGF-β-Smad2/3 signaling in growth arrest and epithelial-to-mesenchymal transition.
  Thien A, Prentzell MT, Holzwarth B, Kläsener K, Kuper I, Boehlke C, Sonntag AG, Ruf S, Maerz L, Nitschke R, Grellscheid SN, Reth M, Walz G, Baumeister R, Neumann-Haefelin E, Thedieck K (2015).
  Dev Cell. 32(5):617-30.
• Inhibition of mTORC1 by astrin and stress granules prevents apoptosis in cancer cells.
  Thedieck K, Holzwarth B, Prentzell MT, Boehlke C, Kläsener K, Ruf S, Sonntag AG, Maerz L, Grellscheid SN, Kremmer E, Nitschke R, Kuehn EW, Jonker JW, Groen AK, Reth M, Hall MN, Baumeister R (2013). Cell. 154(4):859-74
• Surveillance-activated defenses block the ROS-induced mitochondrial unfolded protein response.
  Runkel ED, Liu S, Baumeister R, Schulze E (2013).
  PLoS Genet. 9(3):e1003346
• Cell-nonautonomous signaling of FOXO/DAF-16 to the stem cells of Caenorhabditis elegans.
  Qi W, Huang X, Neumann-Haefelin E, Schulze E, Baumeister R (2012).
  PLoS Genet. 8(8):e1002836.
• SHC-1/p52Shc targets the insulin/IGF-1 and JNK signaling pathways to modulate life span and stress response in C. elegans.
  Neumann-Haefelin E, Qi W, Finkbeiner E, Walz G, Baumeister R, Hertweck M (2008).
  Genes Dev. 22(19):2721-35.
• Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans.
  Tullet JM, Hertweck M, An JH, Baker J, Hwang JY, Liu S, Oliveira RP, Baumeister R, Blackwell TK (2008).
  Cell. 132(6):1025-38
• Regulation of the myosin-directed chaperone UNC-45 by a novel E3/E4-multiubiquitylation complex in C. elegans.
  Hoppe T, Cassata G, Barral JM, Springer W, Hutagalung AH, Epstein HF, Baumeister R (2004).
  Cell. ;118(3):337-49.