Prof. Dr. Roland Schüle

10 selected publications:

• KMT9 controls stemness and growth of colorectal cancer.
  Berlin, B., Cottard, F., Willmann, D., Urban, S., Tirier, S.M., Marx, L., Rippe, K., Schmitt, M., Petrocelli, V., Greten, F.R., Fichtner-Feigl, S., Kesselring, R., Metzger, E. and Schüle, R. (2022)
  Cancer Res. 82, 210-220.
• KMT9 mono-methylates histone H4 Lysine 12 and controls proliferation of prostate cancer cells.
  Metzger, E., Wang, S., Urban, S., Willmann, D., Schmidt, A., Offermann, A., Allen, A., Sum, M., Obier, N., Cottard, F., Ulferts, S., Preca, B.-T., Hermann, B., Maurer, J., Greschik, H., Hornung, V., Einsle, O., Perner, S., Imhof, A., Jung, M. and Schüle R. (2019)
  Nat. Struct. Mol. Biol. 26,361-371.
• Lsd1 regulates skeletal muscle regeneration and fate of satellite cells.
  Tosic, M., Allen, A., Willmann, D., Lepper, C., Kim, J., Duteil, D. and Schüle, R. (2018)
  Nat. Commun. 9, 366.doi 10.1038/s41467-017-02740-5.
• Lsd1 prevents age-programed loss of beige adipocytes.
  Duteil, D., Tosic, M., Willmann, W., Georgiadi, A., Kanouni, T. and Schüle, R. (2017)
  Proc. Natl. Acad. Sci. USA, 114, 5265-5270.
• Assembly of methylated KDM1 and CHD1 drives AR-dependent transcription and translocation.
  Metzger, E., Willmann, D., McMillan, J., Forne, I., Petroll, K., Metzger, P., Gerhardt, S., Maessenhausen, A., Schott, A-K., Espejo, A., Eberlin, A., Wohlwend, D., Schüle, K.M., Schleicher, M., Perner, S., Bedford, M.T., Jung, M., Dengjel, J., Flaig, R., Imhof, A., Einsle, O. and Schüle, R. (2016)
  Nat. Struct. Mol. Biol. 23, 132-139.
• LSD1 promotes oxidative metabolism of white adipose tissue.
  Duteil, D., Metzger, E., Willmann, D., Karagianni, P., Friedrichs, N., Greschik, H., Günther, T., Buettner, R., Talianidis, I., Metzger, D. and Schüle, R. (2014)
  Nat. Commun. 5, 4093 doi: 10.1038/ncomms5093
• Phosphorylation of histone H3T6 by PKCbI controls demethylation at histone H3K4.
  Metzger, E., Imhof, A., Patel, D., Kahl, K., Hoffmeyer, K., Friedrichs, F., Müller, J.M., Greschik, H., Kirfel, J., Ji, S., Kunowska, N., Beisenherz-Huss, C., Günther, T., Buettner, R. and Schüle, R. (2010)
  Nature 464, 792-796.
• Phosphorylation of histone H3 at threonine 11 establishes a novel chromatin mark for transcriptional regulation.
  Metzger, E., Yin, N., Wissmann, M., Kunowska, N., Fischer, K., Friedrichs, N., Patnaik, D., Higgins, J.M.G., Potier, N., Scheidtmann, K.H., Buettner, R. and Schüle, R. (2008)
  Nat. Cell Biol. 10, 53-60.
• Co-operative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression.
  Wissmann, M., Yin, N., Müller, J.M., Greschik, H., Fodor, B.D., Jenuwein, T., Vogler, C., Schneider, R., Günther, T., Buettner, R., Metzger, E. and Schüle, R. (2007)
  Nat. Cell Biol. 9, 347-353.
• LSD1 demethylates repressive histone marks to promote androgen receptor dependent transcription.
  Metzger, E., Wissmann, M., Yin, N., Müller, J.M., Schneider, R., Peters, H.F.M., Günther, T. Buettner, R. and Schüle, R. (2005)
  Nature 437, 436-439.