A quantitative study of the Hog1 MAPK response to fluctuating osmotic stress in Saccharomyces cerevisiae
04.03.2010
Zi Z, Liebermeister W, Klipp E
PLoS One ?5 (3), e9522
Yeast cells live in a highly fluctuating environment especially with respect to the osmolarity changes. We developed a mathematical model and quantitatively investigated the Hog1 response to different changes of osmotic stress. The model analyses indicate that budding yeast cells have been optimized to some specific types of osmotic changes to protect themselves economically. This work also implies that the signaling output can be dynamically controlled by fine-tuning the signal input profiles.
