Quantitative proteomics of the Cav2 channel nano-environments in the mammalian brain
24.08.2010
Müller CS, Haupt A, Bildl W, Schindler J, Knaus HG, Meissner M, Rammner B, Striessnig J, Flockerzi V, Fakler B, Schulte U.
Proc Natl Acad Sci U S A 24;107(34):14950-7
In CNS neurons voltage-activated calcium (Cav) channels by delivering calcium ions (Ca2+) to the cytoplasm initiate a multitude of Ca2+-dependent signaling processes such as transmitter release, gene transcription coupling or axonal growth. All these processes occur in the immediate environment of Cav2 channels - yet the proteins building up these environments were unknown. The present work identifies the proteins residing in the nano-meter vicinity of Cav2 channels and demonstrates that protein networks are responsible for the complex Ca2+ s
