Synthetic Gene Networks in Mammalian Cells

Oktober 2010

Weber W, Fussenegger M

Current Opinion in Biotechnology  21,  5, 690-696  

Current Opinion in Biotechnology    online article

This review highlights the most recent advances in mammalian synthetic biology, and it describes metabolite, hormone, and light-triggered genetic switches as well as the design and construction of synthetic networks that feature tunable oscillations. We conclude by discussing not only the current limitations but also possible ways to transform the construction of synthetic mammalian systems from an art into a predictive engineering discipline.