The physiological roles of phosducin: from retinal function to stress-dependent hypertension

31.10.2010

Beetz N, Hein L

Cell Mol Life Sci. 2011, 68(4):599-612

Cell Mol Life Sci.      online article

This review gives an overview of different aspects of phosducin biology including structure, phylogeny of phosducin family members, posttranscriptional modification, biochemical features, localization, expression levels and physiological functions. Special emphasis is placed on phosducin’s function in the regulation of blood pressure and the clinical relevance will be discussed on the basis of recently published data from gene-targeted mouse models and human genetic studies.