Transcription Factors ETF, E2F, and SP-1 Are Involved in Cytokine-Independent Proliferation of Murine Hepatocytes
26.10.2010
Zellmer S, Schmidt-Heck W, Godoy P, Weng H, Meyer C, Lehmann T, Sparna T, Schormann W, Hammad S, Kreutz C, Timmer J, von Weizsäcker F, Thürmann PA, Merfort I, Guthke R, Dooley S, Hengstler JG, Gebhardt R
Hepatology 52(6):2127-36
We investigated alterations in gene expression patterns during the first 72 hours of C57BL/6N mouse hepatocyte cultured on collagen monolayers which display a high basal frequency of proliferation in the absence of cytokines. The transcription factors ETF, E2F1, and SP-1 seem to play a pronounced role in mediating proliferation-dependent differential gene expression.
