Transgenic expression of human cathepsin B promotes progression and metastasis of polyoma-middle-T-induced breast cancer in mice
06.09.2010
Sevenich L, Werner F, Gajda M, Schurigt U, Sieber C, Müller S, Follo M, Peters C, Reinheckel T.
Oncogene. 2011, 6;30(1):54-64.
Elevated expression of the cysteine protease cathepsin B (CTSB) has been correlated with a poor prognosis for cancer patients. Here we demonstrate that human CTSB expression in mice facilitates progression of PymT-induced breast cancer and lung metastasis, and is associated with enhanced immune
cell infiltration and angiogenesis.
