Ablation of mineralocorticoid receptors in myocytes but not in fibroblasts preserves cardiac function
14.02.2011
Lother A, Berger S, Gilsbach R, Rösner S, Ecke A, Barreto F, Bauersachs J, Schütz G, Hein L.
Hypertension. 2011 Apr;57(4):746-54
Antagonists of the mineralocorticoid receptor improve morbidity and mortality in patients with severe heart failure. The aim of this work was to evaluate whether genetic deletion of mineralocorticoid receptors in mouse cardiomyocytes or fibroblasts in vivo is cardioprotective after chronic left ventricular pressure overload. Thus mineralocorticoid receptors in cardiac myocytes but not in fibroblasts protect from cardiac dilatation and failure after chronic pressure overload.
