Bile Proteomic Profiles Differentiate Cholangiocarcinoma from Primary Sclerosing Cholangitis and Choledocholithiasis
07.01.2011
Lankisch TO, Metzger J, Negm AA, Vo?kuhl K, Schiffer E, Siwy J, Weismüller TJ, Schneider AS, Thedieck K, Baumeister R, Zürbig P, Weissinger EM, Manns MP, Mischak H, Wedemeyer J.
Hepatology
Detection of malignant biliary tract diseases, especially cholangiocarcinoma (CC) in patients with primary sclerosing cholangitis (PSC), is difficult and often too late
for therapy. CE-MS identified disease-specific peptide patterns in patients with choledocholithiasis, PSC & CC. Models for differentiation between the before mentioned conditions were validated. Peptides were sequenced by LC-MS/MS. Bile proteomic analysis discriminates benign conditions from malignant lesions & offers a new possibility for early diagnosis and therapy of CC/PSC.
