Dpp signaling activity requires Pentagone to scale with tissue size in the growing Drosophila wing imaginal disc
25.10.2011
Hamaratoglu F, de Lachapelle AM, Pyrowolakis G, Bergmann S, Affolter M.
PLoS Biol. 2011;9(10):e1001182
Morphogen gradients control patterning during tissue development by assigning different cell fates at different activity thresholds. Here we investigate how morphogen activity expands to adapt to a constantly growing tissue. We address this question quantitatively using the Drosophila wing precursor as a model and show that a BMP signaling gradient that controls organ development expands proportionally (i.e. scales) with the growing tissue. We also identify a newly described feedback regulator of the pathway as a critical mediator of scaling
