Structural Basis for the Function of Tim50 in the Mitochondrial Presequence Translocase.
17.06.2011
Qian X, Gebert M, Höpker J, Yan M, Li J, Wiedemann N, van der Laan M, Pfanner N, Sha B
J Mol Biol. 2011; 411(3):513-9
We report the crystal structure of the intermembrane space domain of yeast Tim50 to 1.83 Å resolution. A protruding beta-hairpin of Tim50 is crucial for interaction with Tim23, providing a molecular basis for the cooperation of Tim50 and Tim23 in preprotein translocation to the protein-conducting channel of the mitochondrial inner membrane.
