Targeting Capacity and Conservation of PreP Homologues Localization in Mitochondria of Different Species
23.05.2011
Alikhani N, Berglund AK, Engmann T, Spånning E, Vögtle FN, Pavlov P, Meisinger C, Langer T, Glaser E
J Mol Biol. 2011;410(3):400-10
Mitochondrial presequences and other unstructured peptides are degraded inside mitochondria by presequence proteases (PrePs) identified in Arabidopsis thaliana , humans , and yeast .The presequences of A. thaliana and human PreP are predicted to consist of 85 and 29 amino acids, whereas the Saccharomyces cerevisiae Cym1 presequence contains only 7 residues. These differences may explain the reported targeting of homologous proteins to different mitochondrial subcompartments.Here we have investigated the targeting capacity of the PreP homologues.
