Comprehensive estimation of input signals and dynamics in biochemical reaction networks
15.09.2012
Schelker M, Raue A, Timmer J, Kreutz C.
Bioinformatics. 2012;28(18):i529-i534
This article presents a new approach which includes the input estimation into the estimation process of the dynamical model parameters by minimizing an objective function containing all parameters simultaneously. We applied this comprehensive approach to an illustrative model with simulated data and compared it to alternative methods. Statistical analyses revealed that our method improves the prediction of the model dynamics and the confidence intervals leading to a proper coverage of the confidence intervals of the dynamic parameters.
