Cytosolic RIG-I-like helicases act as negative regulators of sterile inflammation in the CNS
04.12.2011
Dann A, Poeck H, Croxford AL, Gaupp S, Kierdorf K, Knust M, Pfeifer D, Maihoefer C, Endres S, Kalinke U, Meuth SG, Wiendl H, Knobeloch KP, Akira S, Waisman A, Hartmann G, Prinz M.
Nat Neurosci. 2012; 15(1):98-106
Interferon-? (IFN?) is a first-line therapy for patients with relapsing–remitting multiple sclerosis. This study provides insight into the pathways by which type I IFNs can suppress inflammation in the central nervous system (CNS) and suggests a new mechanism by which these pathways could be targeted therapeutically.
