Glycoprotein Production in Moss Bioreactors
29.09.2011
Decker EL, Reski R
Plant Cell Rep. 2012, 31:453–460
Complex multimeric recombinant proteins such as therapeutic antibodies require a eukaryotic expression system. Transgenic plants may serve as promising alternatives to the currently favored mammalian cell lines or hybridomas. Posttranslational modifications like protein N-glycosylation of the complex type of plant and human proteins resemble each other to a large extent. The uniquely efficient gene targeting mechanism of Physcomitrella patens can be employed to precisely engineer the glycosylation machinery for recombinant products.
