New players in the pathogenesis of focal segmental glomerulosclerosis.

05.07.2012

Schell C, Huber TB.

Nephrol Dial Transplant. 2012; 27(9):3406-12

Nephrol Dial Transplant.       online article

Research efforts of past decades identified FSGS as a podocytopathy with several podocyte molecules being key players in the development and the course of FSGS. Podocytes are crucially involved in the formation of the glomerular barrier and any assault on their delicate physiological balance and architecture can result in the development of proteinuria. The following review article will introduce most recent examples identifying novel players in the complex pathogenesis of FSGS.