Synthesis and Characterization of PEG-Based Drug-Responsive Biohybrid Hydrogels

31.05.2012

Gübeli RJ, Ehrbar M, Fussenegger M, Friedrich C, Weber W.

Macromol Rapid Commun. 2012; 33(15):1280-5

Macromol Rapid Commun         online article

In this study, we present a novel biohybrid material synthesized from biocompatible components being stimulus-responsive to the pharmaceutically approved small-molecule novobiocin. The hydrogel design is based on the gyrase B (GyrB) protein which is covalently grafted to multi-arm polyethylene glycol (PEG) using a Michael-type addition reaction. The switchable properties of this PEG-based hydrogel are favorable for future applications in tissue engineering and as externally controlled drug depot.