A T-bet gradient controls the fate and function of CCR6-ROR?t+ innate lymphoid cells
16.01.2013
Klose CS, Kiss EA, Schwierzeck V, Ebert K, Hoyler T, d'Hargues Y, Göppert N, Croxford AL, Waisman A, Tanriver Y, Diefenbach A.
Nature. 2013;494(7436):261-5
A t mucosal surfaces, the immune system should not initiate inflammatory immune responses to the plethora of antigens constantly present in the environment, but should remain poised to unleash a potent assault on intestinal pathogens. Here we provide evidence that the transcription factor T-bet determines the fate of a distinct lineage of CCR6-ROR?t+ innate lymphoid cells (ILCs) required for immunity to Salmonella infections.
