Alterations of Gab2 signalling complexes in imatinib and dasatinib treated chronic myeloid leukaemia cells

22.04.2013

Halbach S, Rigbolt KT, Wöhrle FU, Diedrich B, Gretzmeier C, Brummer T, Dengjel J.

Cell Commun Signal. 2013;11(1):30

Cell Commun Signal.              online article

By using MS-based proteomics, we have identified new and confirmed known phosphorylation sites and interaction partners of Gab2, which may play an important role in the regulation of this docking protein. Given the growing importance of Gab2 in several tumour entities we expect that our results will help to understand the complex regulation of Gab2 and how this docking protein can contribute to malignancy.