Subcellular mislocalization of the transcription factor NF-E2 in erythroid cells discriminates pre-fibrotic primary myelofibrosis from essential thrombocythemia
13.05.2013
Aumann K, Frey AV, May AM, Hauschke D, Kreutz C, Marx JP, Timmer J, Werner M, Pahl HL
Blood. 2013;122(1):93-9
The WHO classification of myeloproliferative neoplasms (MPN) comprises several entities including essential thrombocythemia (ET), primary myelofibrosis (PMF) and MPN, unclassifiable (MPN, U). We propose that quantitative NF-E2 immunohistochemistry represents a diagnostic tool which can reliably support a differential diagnosis between ET and PMF.
