BMPs regulate msx gene expression in the dorsal neuroectoderm of drosophila and vertebrates by distinct mechanisms
11.09.2014
Esteves FF, Springhorn A, Kague E, Taylor E, Pyrowolakis G, Fisher S, Bier E.
PLoS Genet. 2014;10(9):e1004625.
We show that, while BMPs regulate msx genes during both Drosophila and Zebrafish neuronal patterning, the underlying molecular mechanisms have reversed since the divergence of the two lineages: BMP signaling utilizes similar, yet distinct, regulatory elements to directly repress (fly) or activate (fish) the very same gene. Our findings highlight a mechanism by which BMPs engage the same components to generate opposite instructions and yet arrive at similar outcomes in patterning of the nervous system of vertebrates and invertebrates.
