Burning down the house: IRF7 makes the difference for microglia
13.11.2014
Hagemeyer N, Prinz M
EMBO J. 2014;33(24):2885-6
The endogenous microenvironment of the brain is an essential watchdog to guard over myeloid cell function during diseases. Limiting inflammatory reactions of activated microglia and blood-derived monocytes is a key prerequisite for the resolution of tissue insults. So far, however, it was unknown why monocytes but not microglia are able to shift to an antiinflammatory state during inflammation. The authors found that the transforming growth factor-b1 (TGFb1) prevents activated microglia to switch to an anti-inflammatory state.
