Functional architecture of an optic flow-responsive area that drives horizontal eye movements in Zebrafish
19.03.2014
Kubo F, Hablitzel B, Maschio MD, Driever W, Baier H, Arrenberg AB
Neuron 2014;81(6):1344-1359
Animals respond to whole-field visual motion with compensatory eye and body movements in order to stabilize both their gaze and position with respect to their surroundings. Here, we systematically characterize the neural circuits responsible for these operations using a combination of optogenetic manipulation and in vivo calcium imaging during optic flow stimulation. Area pretectalis neurons are prevalently direction selective, either monocularly or binocularly driven, and hierarchically organized to distinguish between rotational and translational optic flow. Our data predict a wiring diagram of a neural circuit tailored to drive behavior that compensates for self-motion.
