Glial epigenetics in neuroinflammation and neurodegeneration

21.03.2014

Staszewski O, Prinz M

Cell Tissue Res. 2014;356(3):609-16

Cell Tissue Res.       online article

Epigenetic regulation shapes the differentiation and response to stimuli of all tissues and cells beyond what genetics would dictate. Epigenetic regulation acts through covalent modifications of DNA and histones while leaving the nucleotide code intact. Here we highlight current knowledge about epigenetic changes in glial cells occurring during CNS injury, neuroinflammatory conditions as well as neurodegenerative disease. This review offers an overview about the current understanding of epigenetic regulation in glial cells in CNS disease.