Introducing a combinatorial DNA-toolbox platform constituting defined protein-based biohybrid-materials
27.07.2014
Huber MC, Schreiber A, Wild W, Benz K, Schiller SM.
Biomaterials. 2014;35(31):8767-79.
The access to defined protein-based material systems is a major challenge in bionanotechnology and regenerative medicine. Here we introduce an integrative “one-vector-toolbox-platform” (OVTP) approach which is fast, efficient and reliable. The OVTP allows for the assembly, multimerization, intentional arrangement and direct translation of defined molecular DNA-tecton libraries, in combination with the selective functionalization of the yielded protein-tecton libraries with chemical libraries via genetically encoded unnatural amino acids (UAA).
