Loss of collagen VII is associated with reduced transglutaminase 2 abundance and activity

14.04.2014

Küttner V, Mack C, Gretzmeier C, Bruckner-Tuderman L, Dengjel J.

J Invest Dermatol. 2014 Sep;134(9):2381-9

J Invest Dermatol         online article

To gain insights into cellular responses to loss of collagen VII, we undertook a quantitative disease proteomics approach. Absence of collagen VII leads to alterations of intracellular protein compositions and to perturbations in cell adhesion, protein trafficking, and the turnover pathway autophagy. A potential linker of the different cellular phenotypes is transglutaminase 2 (TGM2), a multifunctional enzyme important for protein cross-linking.