Sestrin 2: a regulator of the glomerular parietal epithelial cell phenotype

20.08.2014

Smeets B, Huber TB.

Am J Physiol Renal Physiol. 2014;307(7):F798-9

Am J Physiol Renal Physiol.         online article

for a long time, glomerular parietal epithelial cells (PECs) have mainly been considered to be “innocent bystanders” in the pathology and physiology of the glomerulus. More recently, important functions of PECs have been proposed (for a review, see Ref. 16). PECs have been suggested to be 1) an intrinsic progenitor population to replenish podocytes or proximal tubular cells (15), 2) a second glomerular barrier (13), and 3) important cells involved in the pathogenesis of glomerulosclerosis and crescent formation (5, 17, 18).