Vglut2 and gad expression reveal distinct patterns of dual GABAergic versus glutamatergic cotransmitter phenotypes of dopaminergic and noradrenergic neurons in the zebrafish brain
17.12.2013
Filippi A, Mueller T, Driever W.
J Comp Neurol. 2014;522(9):2019-3
Signaling research into neural transmission has traditionally focused on single neurotransmitter systems. Here, we analyze dopaminergic neurons for vglut2, gad1b and gad2 expression in combination with TH immunoreactivity in four days old larval and 30 days old juvenile zebrafish brains to identify potential GABAergic or glutamatergic cotransmission. Essentially all dopaminergic appear to use GABA or glutamate as cotransmitter. We compare our results with mammalian systems, discuss them in the context of developmental specification of GABAergic and glutamatergic regions in the brain, and in an evolutionary perspective.
