Molecular architecture of the active mitochondrial protein gate
25.09.2015
Shiota T, Imai K, Qiu J, Hewitt VL, Tan K, Shen HH, Sakiyama N, Fukasawa Y, Hayat S, Kamiya M, Elofsson A, Tomii K, Horton P, Wiedemann N, Pfanner N, Lithgow T, Endo T.
Science. 2015;349(6255):1544-8.
The translocase of the outer mitochondrial membrane (TOM complex) imports most mitochondrial proteins. A cross-linking approach revealed the architecture of TOM with three Tom40 beta-barrel channels sandwiched between a central alpha-helical Tom22 receptor cluster and external regulatory Tom proteins. Dynamic coupling of alpha-helical receptors, beta-barrel channels, and chaperones generates a versatile machinery that transports about 1000 different proteins.
