Pharmacology of heart failure: From basic science to novel therapies

Pharmacol Ther.         online article

Chronic heart failure is one of the major challenges in medicine of today. This review provides an overview of current pharmacology and pharmacotherapy in chronic heart failure: The very recently updated clinical guidelines including two novel therapeutic principles, the HCN-channel inhibitor ivabradine and the combined angiotensin and neprilysin inhibitor valsartan/sacubitril, new drugs which are in clinical development, and innovative drug targets which are emerging from preclinical studies.