Distinct roles of Mic12 and Mic27 in the mitochondrial contact site and cristae organizing system
Zerbes RM, Höß P, Pfanner N, van der Laan M, Bohnert M.
J Mol Biol. 2016;428(8):1485-92.
The mitochondrial contact site and cristae organizing system (MICOS) is crucial for maintaining the architecture of the mitochondrial inner membrane. We report the functions of two MICOS subunits. Mic12 and Mic27 play specific roles in the organization of MICOS into two subcomplexes. Mic27 promotes the stability of the membrane-sculpting subcomplex, whereas Mic12 is required for the coupling of both subcomplexes.
