BIOSS
Centre for Biological Signalling Studies

LabDisk for SAXS: a centrifugal microfluidic sample preparation platform for small-angle X-ray scattering

Schwemmer F, Blanchet CE, Spilotros A, Kosse D, Zehnle S, Mertens HD, Graewert MA, Rössle M, Paust N, Svergun DI, von Stetten F, Zengerle R, Mark D.

Lab Chip. 2016;16(7):1161-70.

Lab Chip          online article

We present a centrifugal microfluidic LabDisk for protein structure analysis via small-angle X-ray scattering (SAXS) on synchrotron beamlines. One LabDisk prepares 120 different measurement conditions, grouped into six dilution matrices. Total hands on time is less than 5 min and experiments can be performed by a non-expert.