Sex-specific transcript diversity in the fly head is established during pupal stages and adulthood and is largely independent of the mating process and the germline
Mohr C, Kleiner S, Blanchette M, Pyrowolakis G, Hartmann B.
Sex Dev. 2017;11(2):94-108.
Alternative splicing (AS) generates multiple RNA- and protein-isoforms from a single gene and greatly contributes to the increase of genome complexity. In the present study, and with Drosophila as a model, we globally access and characterize the extent and onset of sex-specific differences in alternative splice patterns in the fly-brain and provide first evidence on their functional relevance in sex-specific development and behavior.
