The loss of SMG1 causes defects in quality control pathways in Physcomitrella patens
Lloyd JPB, Lang D, Zimmer AD, Causier B, Reski R, Davies B.
Nucleic Acids Res. 2018;46(11):5822-5836
Nucleic Acids Res. online article
The process of nonsense-mediated mRNA decay is found in almost every organism and has an important role in the correct balance of the transcript pool in the cell. One of the key players in this pathway is the SMG1 kinase, which phosphorylates the protein UPF1. By using transcriptome-wide analysis of our SMG1 moss knock-out, we revealed next to RNA quality control unexpected influences on DNA repair and unfolded protein response. Thereby SMG1 affects in addition gene regulation and stress response in plants.
