BIOSS Practical

Course 2012
Synthetic Biology and

Signalling

This course will provide a comprehensive introduction to Synthetic

Biology, a rapidly expanding discipline at the borderline between life sciences

and engineering. The participants will become familiar with the key concepts of

Synthetic Biology, of how biologic systems with desired properties can be

constructed in a rational and predictive way. At the example of synthetic

genetic networks and signaling cascades, the participants will design their own

synthetic biologic system and subsequently implement and analyze it in

cell-free systems as well as in higher eukaryotic backgrounds like mammalian

and insect cell culture. The profound theoretical and practical background on

Synthetic Biology concepts will be complemented by lectures from external

specialists providing an overview of how such synthetic approaches can provide

novel solutions to imminent challenges in the health and environmental sector.

Course objectives:

 

• Familiarization with Synthetic

  Biology

• Designing synthetic biological

  networks and signaling cascades

• Cultivation and transfection of

  mammalian and insect cells

• Analyzing signaling processes

  and gene expression in mammalian and insect cells (reporter enzymes,

  immunological methods, FACS)

• Cell-free systems for the

  reconstruction of signaling cascades

• Overview of Synthetic Biology

  applications in the health and environment sector

 

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