Prof. Dr. Bernd Kammerer

Research Interests:

• Regulation of plant biochemical pathways to investigate central metabolism, biosynthesis of secondary metabolites, signalling and stress response
• Biosynthesis and analysis of secondary metabolites from different bacterial strains as new therapeutic agents by „combinatorial biosynthesis”
• Metabolomics to unravel molecular mechanisms involved in Parkinson's disease
• Biomarker identification in breast cancer
• Metabolomics Changes in Ciliopathy: The role of the nephronophthisis Anks6 module in development and tissue homeostasis
• Analysis of the mitochondrial metabolome smORF gene mutants in yeast
• Metabolomic signatures of aggressive prostate cancer

10 selected publications

• Mitochondrial Metabolomics of Sym1-Depleted Yeast Cells Revealed Them to Be Lysine Auxotroph.
  Lagies S, Pan D, Mohl DA, Plattner DA, Gentle IE, Kammerer B.
  Cells. 2023 Feb 22;12(5):692.
• Metabolic and Lipidomic Assessment of Kidney Cells Exposed to Nephrotoxic Vancomycin Dosages.
  Lagies S, Pichler R, Vladimirov G, Gawron J, Bäzner F, Schreiner A, Kadena D, Plattner DA, Lienkamp SS, Kammerer B.
  Int J Mol Sci. 2021 Sep 18;22(18):10111.
• Enzymatic spiroketal formation via oxidative rearrangement of pentangular polyketides.
  Frensch B, Lechtenberg T, Kather M, Yunt Z, Betschart M, Kammerer B, Lüdeke S, Müller M, Piel J, Teufel R.
  Nat Commun. 2021 Mar 4;12(1):1431
• Metabolic Adaptation during nab-Paclitaxel Resistance in Pancreatic Cancer Cell Lines.
  Braun LM, Lagies S, Guenzle J, Fichtner-Feigl S, Wittel UA, Kammerer B.
  Cells. 2020 May 19;9(5):1251.
• Heat Stress-Induced Metabolic Remodeling in Saccharomyces cerevisiae.
  Pan D, Wiedemann N, Kammerer B.
  Metabolites. 2019 Nov 5;9(11):266.
• Impact of Diabetic Stress Conditions on Renal Cell Metabolome.
  Lagies S, Pichler R, Bork T, Kaminski MM, Troendle K, Zimmermann S, Huber TB, Walz G, Lienkamp SS, Kammerer B.
  Cells. 2019 Sep 24;8(10):1141
• Exometabolom analysis of breast cancer cell lines: Metabolic signature.
  Willmann L, Erbes T, Halbach S, Brummer T, Jäger M, Hirschfeld M, Fehm T, Neubauer H, Stickeler E, Kammerer B.
  Sci Rep. 2015 Aug 21;5:13374.
• Metabolome analysis via comprehensive two-dimensional liquid chromatography: identification of modified nucleosides from RNA metabolism.
  Willmann L, Erbes T, Krieger S, Trafkowski J, Rodamer M, Kammerer B.
  Anal Bioanal Chem. 2015 May;407(13):3555-66
• Metabolomic changes in Caenorhabditis elegans lifespan mutants as evident from GC–EI–MS and GC–APCI–TOF–MS profiling.
  Jaeger C, Tellström V, Zurek G, König G, Eimer S, Kammerer B.
  Metabolomics 2014;10(5), 859-876.
• Hedgehog partial agonism drives Warburg-like metabolism in muscle and brown fat.
  Teperino R, Amann S, Bayer M, McGee SL, Loipetzberger A, Connor T, Jaeger C, Kammerer B, Winter L, Wiche G, Dalgaard K, Selvaraj M, Gaster M, Lee-Young RS, Febbraio MA, Knauf C, Cani PD, Aberger F, Penninger JM, Pospisilik JA, Esterbauer H.
  Cell. 2012 Oct 12;151(2):414-26