Prof. Dr. Christoph Borner

We are interested in elucidating the interactions between anti-apoptotic (Bcl-2, Bcl-xL, Mcl-1) and pro-apoptotic (Bim, Puma, Bax/Bak) Bcl-2 family members, uncovering components of apoptosis signaling induced by the RNA virus Semliki Forest (SFV) and the A. fumigatus fungal gliotoxin and studying their relevance in vivo, and identifying the mechanisms by which TNFα sensitizes primary hepatocytes and the liver to FasL-induced apoptosis.

10 selected publications:

• PATA2 restricts OTULIN-dependent LUBAC activity independently of CYLD.
  Griewahn L, Müller-Foxworth M, Peintner L, Wissler M, Weiss M, Brauns-Schubert P, Massoumi R, Borner C, Gross O, Yabal M, Charvet C, Maurer U (2023).
  Cell Rep 42(1):111961.
• Caspase-8 is required for HSV-1-induced apoptosis and promotes effective viral particle release via autophagy inhibition.
  Marino-Merlo F, Klett A, Papaianni E, Drago SFA, Macchi B, Rincón MG, Andreola F, Serafino A, Grelli S, Mastino A*, Borner C* (2022). * shared senior authorship
  Cell Death Differ, Nov 24. doi: 10.1038/s41418-022-01084-y.
• Loss of PKD1/polycystin-1 impairs lysosomal activity in a CAPN (calpain)-dependent manner.
  Peintner L, Venkatraman A, Waeldin A, Hofherr A, Busch T, Voronov A, Viau A, Kuehn EW, Köttgen M, Borner C (2020).
  Autophagy DOI: 10.1080/15548627.2020.1826716.
• Cells grown in three-dimensionsal spheroids mirror in vivo metabolic response of epithelial cells.
  Lagies S, Schlimpert M, Neumann S, Wäldin A, Kammerer B, Borner C, Peintner L (2020).
  Commun Biol 3(1):246.
• Apoptotic stress induces Bax-dependent, caspase-independent redistribution of LINC complex nesprins.
  Lindenboim L, Grozki D, Amsalem-Zafran AR, Peña-Blanco A, Gundersen GG, Borner C, Hodzic D, Garcia-Sáez AJ, Worman HJ, Stein R (2020).
  Cell Death Discov 18(6):90.
• Identification of a novel anoikis signaling pathway using the fungal virulence factor gliotoxin.
  Haun F, Neumann S, Peintner L, Wieland K, Habicht J, Schwan C, Østevold, K, Koczorowska, MM, Biniossek M, Kist M, Busch H, Boerries M, Davis, RJ, Maurer U, Schilling O, Aktories K, Borner C (2018).
  Nat Commun. 9(1):3524.
• TNFα sensitizes hepatocytes to FasL-induced apoptosis by NFκB-mediated Fas upregulation.
  Faletti L, Peintner L, Neumann S, Sandler S, Grabinger T, Mac Nelly S, Merfort I, Huang CH, Tschaharganeh D, Kang TW, Heinzmann F, D’Artista L, Maurer U, Brunner T, Lowe S, Zender L, Borner C (2018).
  Cell Death Dis 9:909.
• Copper-induced cell death and the protective role of glutathione: the implication of impaired protein folding rather than oxidative stress.
  Saporito-Magriñá CM, Musacco-Sebio RN, Andrieux G, Kook L, Orrego MT, Tuttolomondo MV, Desimone MF, Boerries M, Borner C*, Repetto MG* (2018). * share senior authorship
  Metallomics 10:1743-1754. with cover image.
• Dynein light chain 1 induces assembly of large Bim complexes on mitochondria that stabilize Mcl-1 and regulate apoptosis.
  Kumar Singh P, Roukounakis A, Frank DO, Kirschnek S, Kumar Das K, Neumann S, Madl, J, Römer W, Zorzin C, Borner C, Haimovici A, Garcia-Saez A, Weber A, Häcker G (2017).
  Genes Dev 31:1754-1769.
• SPATA2 promotes CYLD activity and regulates TNF-induced NF-κB signaling and cell death.
  Schlicher L, Wissler M, Preiss F, Brauns-Schubert P, Jakob C, Dumit V, Borner C, Dengjel J, Maurer U (2016).
  EMBO Rep. 17(10):1485-1497.