BIOSS

Centre for Biological Signalling Studies

News

Exploring Cutting-Edge Biological Signalling Research in Freiburg

The Lord Mayor of Freiburg, Martin Horn, recently embarked on a visit to the renowned Signalhaus Freiburg, a symbol of research excellence housing the Clusters

March 22, 2024 No Comments

2 new DFG research units at the University of Freiburg

The research unit “UcarE – Urothelial Carcinoma Epigenetics” aims to investigate the biological mechanisms that underlie bladder cancer. The unit’s spokesman is Prof Dr Ian

September 22, 2023 No Comments

First joint Open Day of CIBSS and BIOSS

In June, the two Freiburg signalling research centres CIBSS and BIOSS gave visitors insights into current research topics.

Glowing molecules and the memories of plants:

July 28, 2023 No Comments

Events

Michael Reth

Institute of Biology III (Molecular Immunology), University of Freiburg
Professor

+49 761 203 2718

michael.reth@bioss.uni-freiburg.de

Curriculum vitae

10 selected publications

Antigen receptor function in the context of the nanoscale organization of the B cell membrane. Gold MR, Reth MG (2019. Annu Rev Immunol. Apr 26;37:97-123
A symmetric geometry of transmembrane domains inside the B cell antigen receptor complex. Gottwick C, He X, Hofmann A, Vesper N, Reth M, Yang J (2019). Proc Natl Acad Sci U S A. 116(27):13468-13473.
Continuous signalling of CD79b and CD19 is required for the fitness of Burkitt lymphoma B cells. He X, Kläsener K, Iype JM, Becker M, Maity PC, Cavallari M, Nielsen PJ, Yang, J, Reth, M (2018). EMBO J. 37(11) doi: 10.15252/embj.201797980.
The BTG2-PRMT2 module limits pre-B cell expansion by regulating the CDK4-Cyclin-D3 complex. Dolezal E, Infantino S, Drepper F, Börsig T, Singh A, Wossning T, Fiala GJ, Minguet S, Warscheid B, Tarlinton DM, Jumaa H, Medgeysi D, Reth M (2017). Nat Immunol 18(8): 911-920.
B cell activation involves nanoscale receptor reorganizations and inside-out signaling by Syk. Kläsener K, Maity PC, Hobeika E, Yang J, Reth M. (2014). Elife 3: e02069.
Pillars of Immunology article. Reth M. (2014). J Immunol 192(9):415-416. Reprint of “Antigen receptor tail clue”. Nature (1989).338:383-384.
Matching cellular dimensions with molecular sizes. Reth M. Nat Immunol. 2013 Aug;14(8):765-7.
Oligomeric organization of the B-cell antigen receptor on resting cells. Yang J, Reth M (2010). Nature 467(7314): 465-469.
Deficiency of the adaptor SLP-65 in pre-B-cell acute lymphoblastic leukaemia. Jumaa H, Bossaller L, Portugal K, Storch B, Lotz M, Flemming A, Schrappe M, Postila V, Riikonen P, Pelkonen J, Niemeyer CM, Reth M (2003). Nature 423, 452-456.
Molecular components of the B-cell antigen receptor complex of the IgM class. Hombach J, Tsubata T, Leclercq L, Stappert H, Reth M (1990). Nature 343: 760-762. Reprinted as Pillars of Immunology in J Immunol (2009) 183: 1505-1507