?2B-Adrenoceptor Deficiency Leads to Postnatal Respiratory Failure in Mice
20.08.2010
Haubold M, Gilsbach R, Hein L.
J Biol Chem 285(44):34213-9
Ablation of ?2B-adrenoceptors in mice causes respiratory failure during the first hours after birth due to a defect in lung morphology with significantly reduced alveolar volume and thickened interalveolar septi. Our results indicate that these defects are mediated by activation of sonic hedgehog (SHH) signaling, which is inhibited by ?2B-adrenoceptors.
?2B-adrenoceptors in lung epithelia play an important role in suppressing sonic hedgehog mediated proliferation of mesenchymal cells.
