News

Exploring Cutting-Edge Biological Signalling Research in Freiburg

The Lord Mayor of Freiburg, Martin Horn, recently embarked on a visit to the renowned Signalhaus Freiburg, a symbol of research excellence housing the Clusters of Excellence BIOSS (Biological Signalling Studies) and CIBSS (Centre for Integrative Biological Signalling Studies). Accompanied by Ms....

2 new DFG research units at the University of Freiburg

The research units are aiming to reveal the potential of enzymatic catalysis and investigate the biological mechanisms that underlie bladder cancer.

First joint Open Day of CIBSS and BIOSS

In June, the two Freiburg signalling research centres CIBSS and BIOSS gave visitors insights into current research topics.

Events

BIOSS

A Gene Therapy Technology-based biomaterial for the trigger-inducible release of biopharmaceuticals in mice

25.06.2010

Kämpf M, Christen EH, Ehrbar M, Daoud-El Baba M, Charpin-El Hamri G, Fussenegger M, Weber W

Adv. Funct. Mater. 20, 2534–2538

Adv. Funct. Mater. online article

In this study we describe an implantable small molecule-triggered hydrogel for the inducible release of biopharmaceuticals in mice. The hydrogel consists of polyacrylamide crosslinked by a homodimeric variant of human FK-binding protein (FM). Dimeric FM is dissociated by the small molecule drug FK506 resulting in hydrogel dissolution and the adjustable release of the previously embedded model biopharmaceutical VEGF.