Native GABAB receptors are heteromultimers with a family of auxiliary subunits
13.05.2010
Schwenk J, Metz M, Zolles G, Turecek R, Fritzius T, Bildl W, Tarusawa E, Kulik A, Unger A, Ivankova K, Seddik R, Tiao JY, Rajalu M, Trojanova J, Rohde V, Gassmann M, Schulte U, Fakler B, Bettler B
Nature 13;465(7295):231-5
GABAB receptors are G-protein coupled receptors for g-aminobutyric acid (GABA), the main inhibitory neurotransmitter regulating synaptic transmission and signal propagation in the brain. The proteomic analysis of native GABAB receptor using a newly developed approach identified a family of proteins termed KCTD (= K channel tetramerization domain) that assembles into the GABAB receptors and determines their signal transduction properties as well as their pharmacological profile.
