Quantitative proteomics for the analysis of spatio-temporal protein dynamics during autophagy
16.11.2010
Zimmermann AC, Zarei M, Eiselein S, Dengjel J
Autophagy 6:8, 1009-1016
Stress-induced autophagy leads to major cellular remodeling. During autophagy, the autophagosome is formed that shuttles cellular material to lysosomes for degradation. Quantitative MS-based proteomics is a powerful research strategy for the description of spatio-temporal protein dynamics during autophagy and allows to draw a plastic picture of the cell. In this review we describe recent advances in MS-based proteomics approaches and their implications for autophagy-related research questions.
