Mitochondrial protein turnover: role of the precursor intermediate peptidase Oct1 in protein stabilization.
27.04.2011
Vögtle FN, Prinz C, Kellermann J, Lottspeich F, Pfanner N, Meisinger C.
Mol Biol Cell. 2011; 22(13):2135-43.
We compared the stability of intermediate and mature forms of Oct1 substrate proteins in organello and in vivo and found that Oct1 cleavage increases the half-life of its substrate proteins, most likely by removing destabilizing amino acids at the intermediate’s N-terminus. Thus Oct1 converts unstable precursor intermediates generated by MPP into stable mature proteins.
